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4B064 PREPARATION OF COMPOUNDS BY USING MICRO-ORGANISMS
C12P1/00 -41/00@Z
C12P1/00-41/00@Z AA AA00
PRODUCT 1: INORGANIC COMPOUND 		AA01 AA02 AA03 AA04
. Inorganic compounds . . without metals . . . Hydrogen (H2) . . Metals or metal compounds
AB AB00
PRODUCT 2: HYDROCARBON OR HALOGENATED HYDROCARBON 		AB01 AB02 AB03 AB04 AB05 AB06 AB07 AB08
. Hydrocarbons . . Acyclic saturated hydrocarbons . . . Methane (CH4) . . Acyclic unsaturated hydrocarbons . . Cyclic hydrocarbons . . . Alicyclic hydrocarbons . . . Aromatic hydrocarbons . Halogenated hydrocarbons
AC AC00
PRODUCT 3: CONTAINING OXYGEN, EXCLUDING CARBOXYL COMPOUNDS 		AC01 AC02 AC03 AC04 AC05 AC06 AC07 AC09
. Alcohols . . Acyclic saturated alcohols . . . Ethanol . . . Butanols . . . Polyhydric alcohols . . . . Glycerines . . . . Sorbitol . . Acyclic unsaturated alcohols
AC12 AC13 AC14 AC16 AC17 AC18 AC19
. . containing alicyclic rings . . . containing six-membered alicyclic rings . . . containing condensed rings . . containing aromatic rings . . . monocyclic . . . polycyclic . . . . condensed polycyclic
AC21 AC23 AC24 AC25 AC26
. Ethers ketals or acetals . Aldehydes . . Acyclic aldehydes . . containing alicyclic rings . . containing aromatic rings
AC31 AC32 AC33 AC34 AC35 AC36 AC37 AC38 AC39 AC40
. Ketones . . Acyclic saturated ketones . . . Acetone . . Acyclic unsaturated ketones . . containing alicyclic rings . . . Five-membered rings . . . Six-membered rings . . . polycyclic . . containing aromatic rings . . . polycyclic
AD AD00
PRODUCT 4: CONTAINING OXYGEN, E.G. CARBOXYL COMPOUND OR OTHERS 		AD01 AD02 AD03 AD04 AD05 AD06 AD07 AD08 AD09 AD10
. Carboxyl compounds . . Saturated compounds containing one carboxyl group bound to acyclic carbons . . . Formic acids . . . Acetic acids . . . Propionic acids . . . Butyric acids or isobutyric acids . . . containing rings . . Saturated compounds containing multiple carboxyl groups bound to acyclic carbons . . . Dicarboxylic acids . . . Tricarboxylic acids
AD11 AD12 AD13 AD14 AD15 AD16 AD17 AD18 AD19 AD20
. . Unsaturated compounds containing carboxylic groups bound to acyclic carbon . . . Monocarboxylic acids . . . . Acrylic acids or methacrylic acids . . . . Sorbic acids . . . containing two or more carboxyl groups . . . . Maleic acids . . . . Itaconic acids . . . . Fumaric acids . . . . Dicarboxylic acids with ten or more carbon atoms . . . containing rings
AD21 AD22 AD23 AD24 AD25 AD26 AD27 AD28 AD29 AD30
. . . . containing aromatic rings . . . . . Cinnamic acids . . Halides containing carboxyl groups bound to acyclic carbons . . . Haloalkanoic acids . . containing carboxylic groups bound to non-aromatic ring carbons . . . Three-membered rings or chrysanthemum-carboxylic acids . . . Six-membered rings . . containing carboxylic groups bound to carbon in aromatic rings . . . containing carboxylic groups bound to carbon in six-membered aromatic rings . . Carboxyl compounds containing hydroxyl groups
AD31 AD32 AD33 AD34 AD35 AD36 AD37 AD38 AD39 AD40
. . . containing carboxyl groups bound to acyclic carbons . . . . containing one carboxyl group . . . . . Lactic acids . . . . . Aldonic acids . . . . . Gluconic acids . . . . containing two or more carboxyl groups . . . . . Tartaric acids . . . . . Malic acids . . . . . Citric acids or isocitric acids . . . . . Saccharic acids
AD41 AD42 AD43 AD44 AD45 AD46 AD47 AD48 AD49 AD50
. . . . containing rings . . . containing carboxyl groups bound to ring carbons . . . . containing carboxyl groups bound to carbons in six-membered aromatic rings . . Carboxyl compounds containing ether groups . . . containing carboxyl groups bound to acyclic carbons . . . containing carboxyl groups bound to ring carbons . . Carboxyl compounds containing aldehyde groups (CHO) . . . containing carboxyl groups bound to acyclic carbons . . . containing carboxyl groups bound to ring carbons . . Carboxyl compounds containing ketone groups
AD51 AD52 AD53 AD54 AD55 AD56 AD57
. . . containing carboxyl groups bound to acyclic carbons . . . . Pyruvic acids . . . . Ketoaldonic acids . . . . . 2-Ketogulonic acids . . . . containing rings . . . containing carboxyl groups bound to ring carbons . . Polymeric carboxylic acids
AD61 AD62 AD63 AD64 AD65 AD66 AD67 AD68 AD69 AD70
. Carboxylic acid esters . . of saturated acids containing carboxyl groups bound to acyclic carbons . . . containing no rings in carbon portions of acids . . . . Hydroxyl groups bound to acyclic carbons . . . . Hydroxyl groups bound to ring carbon . . . containing rings in carbon portions of acids . . of unsaturated acids containing carboxyl groups bound to acyclic carbon . . . containing no rings in carbon portions of acids . . . containing rings in carbon portions of acids . . . . containing aromatic rings
AD72 AD73 AD74 AD75 AD76 AD77 AD78 AD79
. . of acids containing carboxyl groups bound to non-aromatic ring carbons . . of acids containing carboxylic acids bound to aromatic ring carbon . . of carboxylic acids containing hydroxyl groups . . . containing carboxyl groups bound to acyclic carbons . . . containing carboxyl groups bound to ring carbons . . . . containing carboxyl groups bound to aromatic ring carbon . . of carboxylic acids containing ether groups . . of carboxylic acids containing aldehyde groups (CHO)
AD82 AD83 AD85 AD87 AD88 AD89 AD90
. . of carboxylic acids containing ketones . . Polymers of carboxylates . Fats fatty oils waxes higher fatty acids or oxidized oils . . Higher fatty acids . . . Higher unsaturated fatty acids . . . . Linoleic acids . . . . Eicosapentaenic acids
AD91 AD92 AD93 AD94 AD99
. having quinoid structures . . containing monocyclic quinoid structures . . containing polycyclic condensed quinoid structures . . . Quinoid structures constituting the ring of condensed ring systems . Oxygen-containing substances not covered by AC or AD
AE AE00
PRODUCT 5: CONDENSED CARBOCYCLIC RING OR HETERO RING CONTAINING NITROGEN, SULFUR OR PHOSPHORUS 		AE01 AE02 AE03 AE04 AE05 AE06 AE07 AE08 AE09 AE10
. Nitrogen-containing organic compounds . . Amides . . Alpha- or beta-amino acids . . . Alanines . . . Valines . . . Leucines . . . Isoleucines . . . Serines . . . Homoserines . . . Threonines
AE14 AE15 AE16 AE17 AE18 AE19 AE20
. . . Cysteines . . . Cystines . . . Methionines . . . Aspartic acids . . . Asparagines . . . Glutamic acids . . . Glutamines
AE24 AE25 AE26 AE27 AE28 AE29 AE30
. . . Arginines . . . Lysines . . . Histidines . . . Citrullines . . . Ornithines . . . Phenylalanines . . . Tyrosines
AE34 AE35 AE36
. . . Tryptophans . . . Prolines . . . Hydroxyprolines
AE41 AE43 AE44 AE45 AE46 AE47 AE48 AE49 AE50
. Organic compounds containing three or more condensed carbocyclic rings . Heterocyclic carbon compounds having oxygen nitrogen or sulfur as hetero atoms. . . Hetero atoms being oxygen only . . . Five-membered rings . . . Six-membered rings . . . Seven or more membered rings . . Hetero atoms being nitrogen only . . . Six-membered rings . . containing diverse hetero atoms e.g. nitrogen or oxygen in the same ring
AE54 AE55 AE56 AE57 AE58 AE59
. . containing two or more hetero rings . . containing two or more hetero rings condensed among themselves or with common carbocyclic rings . . . containing one nitrogen as hetero atom . . . containing two or more nitrogen as hetero atoms . . . containing only nitrogen and oxygen as hetero atoms . . . containing only oxygen as hetero atoms
AE61 AE63
. Sulfur-containing compounds not covered by AB01-AE59 . Phosphorus-containing compounds
AF AF00
PRODUCT 6: SACCHARIDES 		AF01 AF02 AF03 AF04
. Saccharides . . Monosaccharides . . Disaccharides . . Oligosaccharides or saccharides with 3-5 saccharide radicals
AF11 AF12 AF13 AF14 AF15 AF16 AF17
. . Polysaccharides . . . Glucose being constituent sugar . . . . Pullulans . . . . Dextrans . . . . Cyclodextrin . . . Xanthans . . . Uronic acids being constituent sugar
AF21 AF22 AF23 AF24 AF25 AF26 AF27 AF28 AF29
. . containing nitrogen . . . N-glycosides . . . . Nucleotides . . . . . Condensed ring systems containing six-membered rings having two nitrogen atoms . . . . . . Cyclic nucleotides . . . . . . Coenzyme A (CoA) . . . . . Polynucleotides . . . . . Dinucleotides . . . . . . Nicotineamide-adenine dinucleotide phosphate (NADP)
AF33 AF34 AF35 AF36
. . . . Nucleosides . . . . . Condensed ring systems containing six-membered rings having two nitrogen atoms . . . . . . Adenosyl-methionine or homocysteine . . . . Cobalamins
AF41 AF42 AF43 AF44 AF45 AF46 AF47 AF48 AF49 AF50
. . O-glycosides . . . Oxygen atoms of the saccharide radical bound to cyclohexyl radicals . . . . Cyclohexyl radicals substituted by two or more nitrogen atoms . . . . . Fortimicins . . . . . Two saccharide radicals bound only by adjacent carbon and oxygen atoms . . . . . . containing three or more saccharide radicals . . . . cyclohexyl radicals bound to nitrogen in two or more guanido (N-C[=N]-N) groups . . . Oxygen in the polysaccharide radicals bound to three or more carbon condensed rings . . . . Anthracycline compounds . . . Oxygen in the polysaccharide radicals bound to hetero rings by acyclic carbon only
AF52 AF53 AF54 AF56
. . . Oxygen in the polysaccharide radicals bound to hetero rings or heterocyclic condensed rings . . . . Hetero rings having eight or more members and only oxygen in the rings . . . . . Erythromycins . . S-glycosides
AG AG00
PRODUCT 7: PEPTIDE OR PROTEIN 		AG01 AG02 AG03 AG04 AG05 AG06 AG07 AG08 AG09 AG10
. Peptides or proteins . . Cytokines . . . Interleukin (IL) . . . . Interleukin-1 . . . . Interleukin-2 . . . Colony stimulating factor (CSF) . . . Tumour necrosis factors or lymphotoxins . . . Interferon (IFN) . . . . Alpha-interferon . . . . Beta-interferon
AG12 AG13 AG15 AG16 AG18 AG20
. . . . Gamma-interferon . . . Growth factors or growth hormones . . Hormones excluding growth hormones . . . Insulins . . . Erythropoietin (EPO) . . Receptor proteins
AG21 AG23 AG24 AG26 AG27 AG28 AG30
. . Enzyme inhibitors . . . Protease inhibitors . . Albumins . . Immunoglobulins . . . Monoclonal antibodies . . Lectins . . Poisons or toxins
AG31 AG32 AG33 AG35 AG37
. . Antigens . . . Viral proteins . . . . Hepatitis viruses . . Cytochrome C . . Cyclic peptides
AH AH00
PRODUCT 8: OTHER PRODUCT OR PRODUCT WITH UNKNOWN STRUCTURE 		AH01 AH02 AH03 AH04 AH05 AH06 AH07 AH08
. Carotenes . Riboflavins . containing gibbane ring systems . containing naphthacene ring systems . . Tetracyclines . Prostaglandins . Steroids . . containing hetero rings
AH11 AH12 AH13 AH14 AH16 AH19
. Cephalosporins . . Cephalosporin C . . . Derivatives thereof . . Disubstituents in position 7 . Penicillins . Organic substances with unknown structures
BA BA00
PROPERTY 1: MOLECULAR WEIGHT 		BA01 BA02 BA03 BA04 BA05 BA06 BA07 BA08 BA09 BA10
. with less than 100 . with 100 or more but less than 200 . with 200 or more but less than 300 . with 300 or more but less than 400 . with 400 or more but less than 500 . with 500 or more but less than 600 . with 600 or more but less than 700 . with 700 or more but less than 800 . with 800 or more but less than 1000 . with 1000 or more but less than 2500
BA11 BA12 BA13 BA14 BA15 BA16 BA17 BA18
. with 2500 or more but less than 5000 . with 5000 or more but less than 10000 . with 10000 or more but less than 20000 . with 20000 or more but less than 50000 . with 50000 or more but less than 100000 . with 100000 or more but less than 500000 . with 500000 or more but less than 10000 . with 10000 or more
BB BB00
PROPERTY 2:ELEMENTAL ANALYSIS VALUE 		BB01 BB02 BB03 BB04 BB05 BB06 BB07 BB08 BB09 BB10
. Carbon content . . with less than 10% . . with 10% or more but less than 20% . . with 20% or more but less than 30% . . with 30% or more but less than 40% . . with 40% or more but less than 50% . . with 50% or more but less than 60% . . with 60% or more but less than 70% . . with 70% or more but less than 80% . . with 80% or more
BB11 BB12 BB13 BB14 BB15 BB16 BB17 BB18 BB19 BB20
. Hydrogen content . . with less than 4.5% . . with 4.5% or more but less than 5% . . with 5% or more but less than 5.5% . . with 5.5% or more but less than 6% . . with 6% or more but less than 6.5% . . with 6.5% or more but less than 7% . . with 7% or more but less than 8% . . with 8% or more but less than 9% . . with 9% or more
BB21 BB22 BB23 BB24 BB25 BB26 BB27
. Oxygen content . . with less than 10% . . with 10% or more but less than 20% . . with 20% or more but less than 30% . . with 30% or more but less than 40% . . with 40% or more but less than 50% . . with 50% or more
BB31 BB32 BB33 BB34 BB35 BB36 BB37
. Nitrogen content . . with less than 5% . . with 5% or more but less than 10% . . with 10% or more but less than 15% . . with 15% or more but less than 20% . . with 20% or more but less than 25% . . with 25% or more
BB41 BB43 BB45 BB50
. Halogen content . Sulfur content . Phosphorus content . Others (FW with viewpoint symbols)
BC BC00
PROPERTY 3: MELTING POINT OR DECOMPOSITION POINT 		BC01 BC02 BC03 BC04 BC05 BC06 BC07 BC08
. with less than 100 degrees centigrade . with 100 degrees centigrade or more but less than 150 degrees centigrade . with 150 degrees centigrade or more but less than 200 degrees centigrade . with 200 degrees centigrade or more but less than 250 degrees centigrade . with 250 degrees centigrade or more but less than 300 degrees centigrade . with 300 degrees centigrade or more but less than 350 degrees centigrade . with 350 degrees centigrade or more but less than 400 degrees centigrade . with 400 degrees centigrade or more
BD BD00
PROPERTY 4: PH 		BD01 BD02 BD03 BD05
. basic . neutral . acid . amphoteric
BE BE00
PROPERTY 5: SOLUBILITY 		BE01 BE03 BE04 BE05 BE06 BE07 BE08 BE09 BE10
. Water . Organic solvents . . Hexane pentane or petroleum ethers . . Benzene toluene or xylene . . Carbon tetrachlorides . . Chloroform or dichloromethane . . Alcohols or glycerins . . . Methanols . . . Ethanols
BE11 BE12 BE13 BE14 BE15 BE16 BE17 BE18 BE19 BE20
. . Dialkyl ethers . . Dialkylketones or acetone . . Acetic acids formic acids or propionic acids . . Alkyl acetate . . Tetrahydrofuran (THF) . . Dioxanes . . Dimethylformamides (DMF) . . Pyridines or acetonitriles . . Diethyl sulfoxides (DMSO) . Mixed solvents
BE30
. Others (FW)
BF BF00
PROPERTY 6: ISOELECTRIC POINT (IP) 		BF01 BF02 BF03 BF04 BF05 BF06 BF07 BF08 BF09 BF10
. less than or equal to 3.0 . more than 3.0 but less than or equal to 4.0 . more than 4.0 but less than or equal to 5.0 . more than 5.0 but less than or equal to 6.0 . more than 6.0 but less than or equal to 7.0 . more than 7.0 but less than or equal to 8.0 . more than 8.0 but less than or equal to 9.0 . more than 9.0 but less than or equal to 10.0 . more than 10.0 but less than or equal to 11.0 . more than 11.0
BG BG00
PROPERTY 7: COLOUR OR PROPERTY 		BG01 BG02 BG03 BG04 BG05 BG06 BG07 BG08 BG09 BG10
. White or colourless . Yellow . Orange . Red . Green . Blue or indigo . Violet . Properties . . Crystals or crystalline powders . Others (FW)
BH BH00
PROPERTY 8: MEASURING MEANS OR VALUE MEASURED THEREBY 		BH01 BH02 BH03 BH04 BH05 BH06 BH07 BH08 BH09 BH10
. Optical rotation . Infrared absorption spectrum (IR) . Nuclear magnetic resonance (NMR) spectrum . . High-resolution nuclear magnetic resonance (HNMR) e.g. proton nuclear magnetic resonance (PNMR) . . Carbon-13 nuclear magnetic resonance (CNMR) . Ultraviolet absorption spectrum (UV) . Mass spectrum (MS) . Thin-layer chromatography (TLC) . Electrophoresis . Colour reactions
BH20
. Others (FW)
BJ BJ00
PROPERTY 9: FUNCTIONAL GROUP OR PARTIAL CONSTITUTION CORRESPONDING TO PROPERTY 		BJ01 BJ02 BJ03 BJ04 BJ05 BJ06 BJ07 BJ08 BJ09 BJ10
. Alcohols . Ethers . Carbonyl groups . . Carboxylic acids . . Fats . Amines . Groups having sulfur atoms . Halogen atoms or groups having halogen atoms . Groups having unsaturated carbon atoms . Saccharides
BJ11 BJ12 BJ13 BJ14 BJ15 BJ16 BJ20
. Amino groups . . Peptides or proteins . Indole groups . Guanidyl groups . Steroids . Alkaloids . Others (FW)
CA CA00
BIOLOGICAL MATERIAL, E.G. MICRO-ORGANISM OR ENZYME 		CA01 CA02 CA03 CA04 CA05 CA06 CA07 CA08 CA09 CA10
. Micro-organisms (FW) . . Bacteria (FW) . . . Actinomyces (FW) . . . . Streptomyces genus (FW) . . Fungi (FW) . . . Yeasts (FW) . . . Basidiomycetes (FW) . . Unicellular algae (FW) . . Protozoa (FW) . . Animal cells or tissue (FW)
CA11 CA12 CA19 CA20
. . Plant cells plant tissue or calluses (FW) . . Viruses or phages (FW) . Micro-organisms into which foreign genes are introduced . . using cell fusion
CA21 CA22
. Enzymes or enzyme precursors (FW) . . chemically modified (FW)
CA31 CA32 CA33 CA34 CA35 CA36 CA37 CA38 CA39 CA40
. Immobilised micro-organisms or enzymes (FW) . . Carriers . . . Inorganic substances . . . Organic substances . . . . Synthetic resins or rubbers . . . . Saccharides or proteins . . . Shapes . . . . Granules . . . . Fibres or hollow threads . . . . Porous bodies or mesh-like bodies
CA50
. Others (FW)
CB CB00
KIND OF REACTION 		CB01 CB02 CB03 CB04 CB05 CB06 CB07
. Hydrolysis . . of esters . . . of carboxylic acid esters . . . of phosphoric acid esters . . of amides or imides . . . of carboxylic acid amides or carboxylic acid imides . . of glycoside bonds
CB11 CB12 CB13 CB14 CB16 CB17 CB18
. Oxidation . . converting C-H group to C-O-H group . . converting C-O-H group to carbon-to-oxygen double bonds . . converting CH-CH group to carbon-to-carbon double bonds . Reduction . . Hydrogenation . . . converting carbon-to-oxygen double bonds to C-O-H group
CB21 CB22 CB24 CB25 CB26 CB27 CB28 CB29 CB30
. Dehydroxylating . . Formation of carbon-to-carbon double bonds . Acylation e.g. esterification . . using acylating agents containing aromatic carbon rings . . using acylating agents containing no aromatic carbon rings . Phosphorylations . Isomerisations . Unknown reactions . Others (FW)
CC CC00
PROCESS FOR PREPARATION; PROCESS OR APPARATUS FOR TREATMENT 		CC01 CC03 CC04 CC05 CC06 CC07 CC08 CC09 CC10
. characterised by culturing or enzyme reaction processes . . characterised by culturing media (components see CD) . . Processes or conditions during culturing or enzyme reactions . . . Control . . . . Temperature . . . . pH . . . . Concentration . . . . . of dissolved compounds . . . . . of biological materials
CC12 CC13 CC15
. . . Condition of aeration or agitation . . . stopping culturing or enzyme reactions . . recovering biological materials
CC21 CC22 CC24 CC30
. characterised by culturing or enzyme reaction apparatus . . Liquid culturing apparatus . Using genetic engineering techniques . Others (FW)
CD CD00
SUBSTANCE ADDED FOR CULTURING OR ENZYME REACTION 		CD01 CD02 CD04 CD05 CD06 CD07 CD08 CD09 CD10
. Inorganic compounds . . Salts . Organic compounds . . containing oxygen . . . Alcohols . . . Carboxylic acids . . . containing heterocyclic rings . . . Monosaccharides or oligosaccharides . . . . Sugar alcohols
CD11 CD12 CD13 CD14 CD15 CD16 CD17 CD18 CD19 CD20
. . containing atoms other than carbon hydrogen or oxygen . . . containing nitrogen . . . . Amino acids . . . containing silicon . . . containing phosphorus . . Organic macromolecular compounds . . . Addition polymers . . . Condensed polymers . . . Polysaccharides . . . Proteins
CD21 CD22 CD23 CD24 CD25 CD27 CD30
. . Natural substances . . . Plants . . Wastes . . . Plant wastes . . . Animal wastes . Racemic mixtures . Others (FW)
CE CE00
SEPARATION OR PURIFICATION 		CE01 CE02 CE03 CE04 CE05 CE06 CE07 CE08 CE09 CE10
. Distilling or refining . Destructing cells or solubilising living organisms . Sedimentation or agglomeration of products or impurities . . Salting out . . Isoelectric point precipitation . Dialysis or ultrafiltration . Gel filtration . Extraction . Adsorption . Chromatography
CE11 CE12 CE13 CE14 CE15 CE16 CE17 CE20
. . Ion exchange chromatography . . Affinity chromatography . Using monoclonal antibodies . Electrophoresis . Crystallisation . Drying . . Freeze-drying . Others (FW)
DA DA00
FIELD OF APPLICATION; USEFULNESS 		DA01 DA02 DA03 DA04 DA05 DA06 DA07 DA08 DA10
. Medicine; Prevention or treatments . . Antibiotics . . . for humans . . . for animals . . Tumouricidal properties . . Fat or cholesterol reduction . . Carbohydrate reduction . . Medications for counteracting inflammation or painkilling . Foods or brewing
DA11 DA12 DA13 DA14 DA15 DA16 DA17 DA18 DA19 DA20
. Industries on agriculture forestry or fisheries; Agrichemicals . . insecticidal antibacterial or herbicidal . Analyses or diagnoses . . Tumours e.g. cancers . . Infectious diseases . Chemical engineering; Purification or environmental protection . . Coagulation or clarification . . Deodorisation . . Washing or bleaching . Others (FW)
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