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4C075 Cephalosporin compounds
C07D501/00 -501/62
C07D501/00-501/62 AA AA00
CLAIM SPECIFICATION 		AA01 AA02 AA03 AA06 AA07 AA08 AA10
. Heterocyclic compounds containing 5-thia-1-azabicyclo [4,2,6] octane ring system . Compounds with one or more oxygen attached to the 5-thia position, wherein oxygens may also form a heterocyclic ring . Unspecified groups . Unspecified group directly bonded to 7-position . Compounds containing hydroxy and/or alkoxy group . Carboxylic acid derivatives (e.g., acids, salts or protective esters thereof) . Others
BB BB00
DOUBLE BONDS BETWEEN CYCLIC ELEMENTS AND BETWEEN CYCLIC AND NON-CYCLIC ELEMENTS 		BB01 BB02 BB03 BB04 BB05 BB06 BB07 BB08 BB10
. Oxygen doubly bonded directly to 8-position . . Double bonds between 3- and 4-position as well . . Double bonds between 2- and 3-position as well . . Oxygen doubly bonded to 2-position as well . . Oxygen doubly bonded to 3-position as well . . Oxygen doubly bonded to 7-position as well . . Oxygen doubly bonded to 2- and 3-position as well . . Oxygen doubly bonded to 2-, 3-, 7-, and 8-position . Others
CC CC00
7-POSITION SUBSTITUENT 		CC01 CC02 CC03 CC04
. Unsubstituted . One substituent . Two substituents . . One of two substituents is hydroxy or alkoxy
CC11 CC12 CC13 CC14 CC16 CC17 CC19
. Substituent is carboxylic acid amide . . The substituent is an unsubstituted aliphatic carboxylic acid derivative . . The amide is an unsubstituted aliphatic group or aromatic aliphatic carboxylic acid derivative . . The amide is an unsubstituted aliphatic complex ring aliphatic carboxylic acid derivative . . The amide is an aromatic carboxylic acid derivative . . The amide is a complex ring containing carboxylic acid derivative . . The amide is an aliphatic carboxylic acid derivative
CC22 CC23 CC24 CC25 CC26 CC27 CC28 CC29 CC30
. . The amide substituent is on the aliphatic group of an aromatic aliphatic carboxylic acid derivative . . . C=C directly bonded to carboxamide carbon . . . Carbon arom having three bonds to hetero atoms with at the most one bond to halogen directly bonded to carboxamide carbon . . . C-O directly bonded to carboxamide carbon . . . . O is hydroxy or alkoxy . . . C-S directly bonded to carboxamide carbon . . . . S is thiol or thioether . . . Nitrogen directly bonded to carboxamide carbon . . . . Nitrogen substituent is further bonded to hydroxy or alkoxy
CC32 CC33 CC34 CC35 CC36 CC37 CC38 CC39 CC40
. . The amide substituent is on the aliphatic group of a complex ring aliphatic carboxylic acid derivative . . . C=C directly bonded to carboxamide carbon . . . Carbon arom having three bonds to hetero atoms with at the most one bond to halogen directly bonded to carboxamide carbon . . . C-O directly bonded to carboxamide carbon . . . . O is hydroxy or alkoxy . . . C-S directly bonded to carboxamide carbon . . . . S is thiol or thioether . . . Nitrogen directly bonded to carboxamide carbon . . . . Nitrogen substituent is further bonded to hydroxy or alkoxy
CC41 CC42 CC43 CC44 CC45 CC46
. Heterocyclic ring in 7-position . . Oxygen-containing heterocyclic ring . . Sulfur-containing heterocyclic ring . . Nitrogen-containing heterocyclic ring . . . Thiazole or hydrogenated thiazole . . . Thiadiazole or hydrogenated thiadiazole
CC51 CC52 CC53 CC54 CC55 CC60
. Variants wherein the amino nitrogen is not directly attached . . Unsubstituted amino groups . . Substituted amino groups . . Amino group is part of a heterocyclic ring . . Amino nitrogen double-bonded to the ring . Others
CD CD00
END SUBSTITUENT IN THE 7-POSITION 		CD01 CD02 CD03 CD04 CD05 CD06 CD07 CD08 CD09 CD10
. Hydrogen . Hydrocarbon . . Aliphalic hydrocarbon . . . Alkyl . . . Alkenyl . . . Alkynyl . . . Alicyclic . . . Aromatic aliphatic . . Aromatic . Heterocyclic
CD11 CD12 CD13 CD14 CD15 CD16 CD17
. Substituent hydrocarbons . . Halogen-containing . . Oxygen-containing . . Sulfur-containing . . Nitrogen-containing . . Carboxyl group or derivative . . Heterocyclic group
CD22 CD23 CD24 CD25 CD26 CD27 CD28
. . Aliphatic . . . Alkylene . . . Alkenylene . . . Alkynylene . . . Alicyclic . . . Aromatic aliphatic . . [C] of CD12 to CD17 is aromatic
CD31 CD32 CD33 CD35 CD37 CD40
. Acyl group . . Acyl group derived from carbocyclic acid or its analog . . . Heterocyclic . . . Acyl group derived from aminocarboxylic acid . . Acyl group derived from carbonic acid or its analog . Others
DD DD00
3-POSITION SUBSTITUENT 		DD01 DD02 DD03 DD05 DD06 DD07 DD08 DD09
. Unsubstituted . One substituent . Two substituents . Hydrocarbons . . Aliphatic . . . Alicyclic . . . Aromatic aliphatic . . Aromatic
DD11 DD12 DD13 DD14 DD15 DD16 DD18 DD19 DD20
. Substituent hydro carbons . . Oxygen-containing substituent . . . Alkoxy . . . . Alkoxy carbonyl-containing substituent . . . . . Methoxy carbonyl methyl substituent . . . . Alkoxy substituted heterocyclic ring containing substituent . . Sulfur-containing substituent . . . Thioether-containing substituent . . . . Thioalkyl substituted heterocyclic ring containing substituent
DD22 DD23 DD24 DD25 DD26 DD28 DD29 DD30
. . Acyclic amine containing substituent . . . Alkylamino group substituent . . . . Quaternary amino group containing substituent . . . . Aminomethyl substituted heterocyclic containing substituent . . . . Quaternary amino group wherein the quarternary amino nitrogen is part of a heterocyclic ring . . Heterocyclic ring containing substituent . . . Alkyl-substituted heterocyclic ring conatining substituent . . Unsaturated hydrocarbon substituent
DD31
. Heterocyclic substituent
DD41 DD42 DD43 DD44 DD45 DD46 DD47 DD48
. . Heterocyclic substituent consisting of a single ring or a heterocyclic ring condensed with a carbon ring . . Oxygen-containing heterocyclic ring . . Sulfur-containing heterocyclic ring . . Nitrogen-containing heterocyclic ring . . . One ring nitrogen . . . Two ring nitrogen . . . Three ring nitrogen . . . Four ring nitrogen
DD51 DD52 DD53 DD54 DD55 DD56 DD60
. Hetero atoms or carboxylic acid and derivatives . . Halogen . . Oxygen . . Sulfur . . Nitrogen . . Carbon atom having 3 bonds to hetero atoms with, at the most, 1 bond to halogen . Others
EE EE00
4-POSITION SUBSTITUENT 		EE01 EE02 EE03 EE05 EE06 EE07 EE08 EE09 EE10
. Unsubstituted . One substituent . Two substituent . Carboxyl group . Carboxylic acid salt or ester containing substituent . . Alkyl ester containing substituent . . Substituted alkyl ester containing substituent . . . Haloalkyl ester substituent . . . Oxyalkyl ester substituent
EE11 EE12 EE13 EE14 EE15 EE16 EE18 EE19 EE20
. . . . Oxycarbonyl alkyl group substituent . . . . Alkylcarbonate conatining substituent . . . Sulfur-containing carbonyl oxy substituent . . . Nitrogen-containing carbonyl oxy substituent . . Carbonyl oxy substituent directly bonded to a heterocyclic group . . . Oxygen-containing heterocyclic group . COO directly bonded to the ring . . COO metal directly bonded to the ring . Others
FF FF00
2-POSITION SUBSTITUENT 		FF01 FF02 FF03 FF05 FF06 FF07 FF08 FF10
. Unsubstituted . One substitution . Two substitution . Hydrocarbon . Substituent hydrocarbon . Heterocyclic . Hetero atom or carboxylic acid and derivatives . Others
GG GG00
1-POSITION SUBSTITUENT 		GG01 GG02 GG03 GG05 GG10
. Unsubstituted . One substitution . Two substitution . Oxygen . Others
HH HH00
5-, 6-, OR 8- POSITION SUBSTITUENT 		HH01 HH02 HH10
. Hydrogen or oxygen substituent . Substituents other than hydrogen or oxygen . Others
JJ JJ00
CONDENSED WITH OTHER RINGS 		JJ01 JJ02 JJ03 JJ04 JJ05 JJ06 JJ07 JJ08 JJ10
. Ortho condensed . . Condensed in 3- or 4- position . . . Condensed with oxygen-containing heterocyclic ring . . . Condensed with sulfur-containing heterocyclic ring . . . Condensed with nitrogen-containing heterocyclic ring . Spiro condensed . . Condensed in 2- position . . Condensed in 3- position . Others
KK KK00
FORMS OF COMPOUNDS 		KK01 KK02 KK03 KK05 KK06 KK10
. Specific salt . Solvate . Hydrate . Complex . Crystalline . Others
LL LL00
USES OR PURPOSE 		LL01 LL02 LL03 LL04 LL05 LL06 LL08 LL10
. Antibacterial agent . . Improved oral absorption . . Improved stability . . . Reduced moisture absorption . . Protection of intestinal colonies . . Reduced pain during injection . Intermediate body . Others
MM MM00
PREPARATION METHODS 		MM01 MM02 MM03 MM04 MM05 MM08 MM09 MM10
. Preparation from cephalosporin ring compound . . Preparation relating to the 7-position . . . Addition of amino group to the 7-position . . . . Addition of imino group to the 7-position . . . . Deacylating of 7-position acylamino group . . . Preparation of 7-acylamino substituted compounds . . . . Preparation from a corresponding compound wherein the 7-position substitution is nitrogen double bonded to carbon . . . . Preparation from 7-acylamino substituted compounds per se
MM12 MM13 MM14 MM15 MM16 MM18 MM20
. . . . . Preparation by acyl exchange reaction . . . . Acylation of 7-amino cephalosporin . . . . . Inclusion of acid reactant . . . . . Base in reaction system . . . . . Neutral testing agent in reaction . . . Preparation of a compound wherein nitrogen, which is double-bonded to carbon, is bonded to the 7-position . . . Preparation of a compound wherein a substituted amino group is bonded to the 7-position
MM22 MM25 MM26 MM27 MM28 MM29 MM30
. . . Introduction of additional substituents in the 7-position . . Preparation relating to the 3-position substituent . . . Hydrogenation . . . Formation of hydrocarbon group . . . . Hydrocarbon is methyl . . . . Hydrocarbon is methylene . . . Formation of substituted hydrocarbon group
MM32 MM33 MM34 MM35 MM37 MM38 MM40
. . . . Halogen-containing hydrocarbon . . . . Oxy-containing hydrocarbon . . . . . Hydroxy-containing hydrocarbon . . . . . Alkoxy carbonyl containing hydrocarbon . . . . Sulfur-containing hydrocarbon . . . . . Containing sulfur and another substituted hydrogen . . . . Nitrogen-containing hydrocarbon
MM42 MM43 MM44 MM45 MM46 MM47 MM49 MM50
. . . . . Quaternary nitrogen is part of a heterocyclic ring . . . . Heterocyclic ring substituted hydrocarbon . . . . Addition of a non-specific substituent to 3-position . . . . CHO group addition . . . Adding nitrogen or other element to 3-position . . . . Halogen addition . . Simultaneous chemical modification of 3- and 7-positions . . Preparation relating to the 2-position
MM52 MM53 MM54 MM57 MM58 MM59 MM60
. . Preparation relating to the 1-position . . . Bonding of one or two oxygen atoms to the 1-position . . . Removal of oxygen atoms from the 1-position . . Preparation relating to the 4-position . . . Addition of carboxylic acid group to 4-position . . . . Addition by esterification . . . . Addition by ester exchange
MM62 MM63 MM66 MM67 MM68 MM69 MM70
. . . . Addition by ester hydrolysis . . . . Addition by halogenation . . Preparation relating to double bonds in the ring system . . . Creation of a double bond in the 3,4 positions . . . Creation of a double bond in the 2,3 positions . . . Removal of double bond from 2,3 or 3,4 positions . . . Isomerizing 3,4 double bond to the 2,3 position
MM71 MM72 MM73 MM74 MM76 MM77 MM78 MM79
. Synthesis from compound that does not contain cephalosporin . . 1-thia-3,6-diaza-bicyclo [3,2,0] heptane . . 1-thia-5-aza-bicyclo [4,2,0] octane . . . Divalent sulfur bonded directly to the ring sulfur . . 1-thia-4-aza-bicyclo (3,2,0) heptane reactant . . . Acid in reaction system . . . Base in reaction system . . . Neutral testing agent in reaction system
MM81 MM82 MM90
. Refining, separation, or stabilization . . Crystallization . Others
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